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哈药集团世一堂制药厂是国家重点大型制药企业之一，位于全国中药行业50强之中，是国家GMP认证企业。

企业现有员工800余人，拥有7个生产车间、2个分公司（饮片公司、华纳公司），产品涵盖11大剂型、200余个品种。有多种产品荣获国际、国家、省市级的优质产品称号。企业多次被评为国家、行业及省市级先进企业，企业同时也是联合国计划开发署中国成员单位、驰名保护保护组织成员。世一堂是黑龙江省唯一的国际注册商标。它集商标名称、产品品牌和企业品牌三者合一，在黑龙江省历届商标评比中均名列前茅，品牌无形资产评估超过十亿元。

世一堂创建于1903年（清朝光绪二十九年），创建之初为一间老药铺，后改造为制药作坊。

民国初年，世一堂拥有吉林老号、阿城世一堂、道外世一堂、道里世一堂四家分店，呈现出连锁经营的雏形。

1915年（民国四年），世一堂生产的鹿角胶走出国门，代表国货精品参加首届"国际巴拿马博览会"并获得金奖。

此后，世一堂发展进入鼎盛时期，在华北地区陆续开设了十几家分号，声名鹊起，与北京同仁堂齐名，自此在药界留下了“里有同仁，外有世一”之佳话。

在动乱年代残存下来以后，40年代世一堂在党和政府的扶植下重获新生。

50年代初，道里世一堂月平均销售额55000元，年销售额540000元。

1956年，世一堂实行公私合营，世一堂药店划归哈尔滨市药材公司领导，成立2个门市部，即道里世一堂门市部和道外世一堂门市部，保留原世一堂药店称号，恢复传统中药材的加工生产。

1986年起，企业先后投入2亿元，对世一堂进行异地扩建改造。新厂区搬迁至道里区达康路18号，占地13.4万平方米。

1990年，企业实施科技兴厂战略，大力进行技术投资，开发新产品，提高产品质量，树立品牌观念。企业同时在马德里成员国进行了国际注册，在几十个国家取得了商标专用权，成为当时黑龙江省唯一一家拥有国际注册商标的企业。

1996年，世一堂制药厂被国内贸易部认证为“中华老字号”企业。

2000年，作为哈药集团子公司的世一堂制药厂正式更名为哈药集团世一堂制药厂。

2005年6月，哈药集团世一堂制药厂被中国商业联合会批准为“中华老字号”会员单位。

2006年，哈药集团世一堂制药厂注册商标“世一堂”被中华人民共和国商务部认定为“中华老字号”。世一堂在首届中华老字号品牌价值百强榜中位列第34位，是黑龙江省进入“百强榜”仅有的几家制药企业之一。

2008年4月，根据哈药集团战略发展需要，哈药集团世一堂制药厂与哈药集团中药二厂、哈药集团中药三厂进行整合，形成了一个总资产超过10亿，集销售、生产、科研为一体，传统中药与现代中药齐备的大型中药专业生产基地，综合实力进一步增强。

2009年6月，哈药集团世一堂制药厂被黑龙江省商务厅认定为黑龙江老字号。

Shiyitang pharmaceutical factory of Harbin Pharmaceutical Group is one of the national key large pharmaceutical enterprises, which is located in the top 50 of the national traditional Chinese medicine industry, and is a national GMP certified enterprise. The company has more than 800 employees, 7 production workshops and 2 branches (Yinpian company and Warner company). Its products cover 11 dosage forms and more than 200 varieties. A variety of products have won the title of international, national, provincial and municipal high-quality products. The enterprise has been rated as a national, industrial, provincial and municipal advanced enterprise for many times. The enterprise is also a member of the United Nations Development Programme in China and a well-known protection organization. Shiyitang is the only international registered trademark in Heilongjiang Province. It integrates brand name, product brand and enterprise brand, and ranks first in all trademark appraisals in Heilongjiang Province. The intangible assets of the brand are valued at more than one billion yuan. Shiyitang was founded in 1903 (the 29th year of Guangxu in the Qing Dynasty). At the beginning of its establishment, it was an old drugstore and later transformed into a pharmaceutical workshop. In the early years of the Republic of China, Shiyitang had four branches, i.e. Jilin laohao, Acheng Shiyitang, daowaishiyitang and Daoli Shiyitang, showing the prototype of chain operation. In 1915 (the fourth year of the Republic of China), the antler glue produced by Shiyitang went out of the country and participated in the first "international Panama Expo" on behalf of the national products and won the gold medal. Since then, the development of Shiyitang has entered its heyday. In North China, more than a dozen semicolons have been set up, which have gained fame and become as famous as Beijing Tongrentang. Since then, the story of "there are colleagues in the pharmaceutical industry, and there is a world in the outside" has been left. After surviving the turbulent years, Shiyitang was reborn in the 1940s with the support of the party and the government. In the early 1950s, the average monthly sales volume of Daoli Shiyitang was 55000 yuan, and the annual sales volume was 540000 yuan. In 1956, Shiyitang implemented the public-private joint venture. Shiyitang drugstore was assigned to the leadership of Harbin pharmaceutical company, and 2 sales departments were established, namely, the Sales Department of Daoli Shiyitang and the Sales Department of daowaishiyitang. The original title of Shiyitang drugstore was retained, and the processing and production of traditional Chinese medicine was resumed. Since 1986, the enterprise has invested 200 million yuan in the expansion and transformation of Shiyitang. The new plant area is relocated to No. 18, Dakang Road, Daoli District, covering an area of 134000 square meters. In 1990, the enterprise carried out the strategy of building up the factory with science and technology, invested heavily in technology, developed new products, improved product quality and established brand concept. At the same time, the enterprise has carried out international registration in Madrid member countries and obtained the exclusive right of trademark in dozens of countries, becoming the only enterprise with internationally registered trademark in Heilongjiang Province at that time. In 1996, Shiyitang pharmaceutical factory was certified as "China time honored brand" by the Ministry of domestic trade. In 2000, Shiyitang pharmaceutical factory, a subsidiary of Harbin Pharmaceutical Group, was officially renamed as Shiyitang pharmaceutical factory of Harbin Pharmaceutical Group. In June 2005, Shiyitang pharmaceutical factory of Harbin Pharmaceutical Group was approved as a member unit of "China time honored brand" by China Federation of Commerce. In 2006, the registered trademark "Shiyitang" of Harbin Pharmaceutical Group Shiyitang pharmaceutical factory was recognized as "China time honored brand" by the Ministry of Commerce of the people's Republic of China. Shiyitang ranked thirty-fourth in the first China top 100 brand value list, and is one of the only pharmaceutical enterprises in Heilongjiang province to enter the "top 100 list". In April 2008, according to the needs of the strategic development of Harbin Pharmaceutical Group, Shiyitang pharmaceutical factory of Harbin Pharmaceutical Group was integrated with the second factory of traditional Chinese medicine of Harbin Pharmaceutical Group and the third factory of traditional Chinese medicine of Harbin Pharmaceutical Group, forming a large-scale specialized production base of traditional Chinese medicine with a total assets of more than 1 billion, integrating sales, production and scientific research. The comprehensive strength was further enhanced. In June 2009, Shiyitang pharmaceutical factory of Harbin Pharmaceutical Group was recognized as Heilongjiang time-honored brand by Heilongjiang Provincial Department of Commerce.

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