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清光绪二十八年（1902年），北京同仁堂少东家、乐家第12代传人乐镜宇（电视剧《大宅门》主人公白景琦原型）捐山东候补道来到济南，逢故交山东巡抚杨士骧，受其委托筹办“山东官药局”。光绪三十二年（1906年）位于院前大街的“山东官药局”成立，乐镜宇出任官药局掌柜。光绪三十三年（1907年），乐镜宇注资2000大洋，购得了山东官药局承受权，更名为“宏济堂药店”。

宣统元年（1909年）,乐镜宇感悟趵突泉东流水云雾润蒸，甘甜清冽，聚精纳气之灵秀，在济南趵突泉畔东流水设“宏济胶厂”。鉴于当时生产的阿胶皆有腥秽气味，乐镜宇于是大量查阅古医籍药典，遍访制胶名家，并不惜重金从阳谷县聘请制胶奇人刘怀安来济南。乐镜宇对阿胶质量要求很高，不怕费工费料，必求精良。宏济堂东流水阿胶采“天下第一泉”泉水之菁；山东独有德州黑驴之新鲜驴皮；配以多味名贵药材；独创“九昼夜精提精炼法”（非物质文化遗产）；了除了常法熬胶之腥臭气味，胶块色如琥珀、清透甜韵、鼓舞气血，更易吸收，疗效更宏，成就宏济堂东流水上品阿胶。

1909年，进贡隆裕皇后，被清皇宫奉为珍品“九天贡胶”；

1914年，宏济堂东流水阿胶获得“山东全省最优等金牌褒奖”；

同年，又获得铁道实业部颁发的“超等”奖状，此乃当时华夏制造业之最高褒奖；

1915年，宏济堂东流水阿胶获巴拿马万国博览会优等金牌奖，被时人誉为“国胶”，成为中国第一个走向世界、在国际上获得金奖的中药制品。

据《济南中医药志》载，宏济堂东流水阿胶“有福、禄、寿、财、禧等12种型号”，产品成色之佳、疗效之宏都超过了东阿、阳谷产品，宏济堂东流水阿胶在国内销于上海、广州、浙江、福建、安徽等省，在国外行销马来西亚、新加坡、印度尼西亚、日本等国。当时阿胶市场几为宏济堂东流水所独占。受到清廷官员、贵胄、达人及清末民初袁世凯等当权者、中华民国先驱孙中山、中华人民共和国缔造者毛泽东等代代崇用。

宏济堂东流水阿胶的成功促进了宏济堂事业的发展，从1910年起，乐镜宇先后在北京前门外大街蒋家胡同建立了“济南宏济堂参茸阿胶庄”；在济南商埠建立了宏济堂西号，在济南经二纬一路建宏济堂中号，在济南西关开药栈等。上世纪三十年代，宏济堂总收入已占同仁堂总号的三分之二，济南宏济堂也与北京同仁堂，杭州胡庆余堂并誉为“中国三大名堂”。乐镜宇因而也在掌管济南宏济堂的同时，主掌北京同仁堂。

宏济堂东流水阿胶厂的部分房间在1925年—1927年，还作为山东省委机关所在地，主要领导人都在此居住或办公。

建国后，年事已高、多病的乐镜宇仍然受到毛主席、周总理的邀请，由其侄子乐松生代为荣幸受到毛主席、周总理的二次接见。

1955年7月，济南市人民政府对以宏济堂为龙头的全市所有中药老字号进行公私合营改造，成立了济南市药材公司（济南药材站），1996年改制为济南药业集团有限责任公司，即现在山东宏济堂医药集团有限公司的前身。

2008年，为了挖掘珍贵的中医药产品，恢复传统的宏济堂东流水阿胶生产技艺，山东宏济堂医药集团有限公司投资成立“山东宏济堂阿胶有限公司”，有针对性地调配人员、寻访和重用仍然健在的老药工、老技工，传授宏济堂东流水阿胶制作技艺，对这一宝贵的中药产品进行保护性开发。经过近年来的努力，山东宏济堂阿胶有限公司按照老传统、老工艺、老配方、老选料，“九提九炙”、纯手工制作的宏济堂东流水阿胶在中断近60年后恢复生产上市。2010年10月，央视CCTV4《走遍中国》拍摄的《复活的古胶》在世界170个国家播出。去年以来，央视CCTV4、CCTV7、CCTV12频道又先后播出了《走遍中国——黄马褂》、《国宝档案——九天贡胶》、《乡土——小楼春秋》、《见证——古胶传奇》等反映宏济堂东流水阿胶历史文化的专题纪录片，对这一极具历史文化特色产品进行了充分的肯定和深度报道。

2010年，宏济堂东流水阿胶“九提九炙”制作技艺已被列入非物质文化遗产；被济南市评为十大民俗文化特色产品。

In 1902, Yue Jingyu (the prototype of Bai Jingqi, the protagonist of the TV drama "big house gate"), the 12th generation successor of Beijing Tongrentang and Yue family, donated Shandong alternate road to Jinan. He made friends with Yang Shihui, the governor of Shandong Province, and was entrusted by him to organize "Shandong official medicine bureau". Guangxu 32 years (1906) located in front of the main street, "Shandong official medicine bureau" was established, Le Jingyu as the manager of the official medicine bureau. In the 33rd year of Guangxu (1907), Le Jingyu invested 2000 yuan and bought the right of Shandong government pharmaceutical bureau to bear it, which was renamed as "hongjitang Drugstore". In the first year of Xuantong (1909), Le Jingyu realized that Baotu Spring was steaming with water, cloud and mist, sweet and clear, and smart, gathering essence and absorbing Qi. He set up "Hongji rubber factory" in Dongliu water beside Baotu Spring in Jinan. In view of the smell of fishy and filthy donkey hide gelatin produced at that time, Le Jingyu went through a large number of ancient medical books and pharmacopoeia, visited famous glue makers, and spared no effort to hire Liu Huai'an, a rubber maker from Yanggu County, to Jinan. Le Jingyu has high quality requirements for donkey hide gelatin. He is not afraid of labor and materials, but must be excellent. In the east of hongjitang, Ejiao collects the essence of "the best spring in the world"; Shandong has the unique fresh donkey skin of Dezhou black donkey; it is equipped with many precious medicinal materials; it has created the "nine day and night refined method" (intangible cultural heritage); in addition to the smell of the regular method of boiling gum, the rubber block is amber, clear and sweet, and it can stimulate Qi and blood, which is easier to absorb, and has greater curative effect, making it the best water in the east of hongjitang Donkey hide gelatin. In 1909, tribute was paid to the empress of Longyu, who was regarded as the treasure of "nine days tribute glue" by the imperial palace of Qing Dynasty; in 1914, hongjitang dongshuiejiao won the "best gold medal award in Shandong Province"; in the same year, it also won the "super grade" award issued by the Ministry of railway industry, which was the highest praise of Chinese manufacturing industry at that time; in 1915, hongjitang dongshuiejiao won the best gold medal of Panama world expo, and was awarded the gold medal of Panama world expo At that time, it was known as "national glue" and became the first Chinese traditional medicine product that went to the world and won the gold medal in the world. According to the records of Jinan traditional Chinese medicine, hongjitang dongshuiejiao "has 12 models, such as fortune, fortune, longevity, wealth, and happiness". Its products are superior in quality and curative effect. Hongjitang dongshuiejiao is sold in Shanghai, Guangzhou, Zhejiang, Fujian, Anhui and other provinces at home, and in Malaysia, Singapore, Indonesia, Japan and other countries abroad. At that time, Ejiao market was monopolized by hongjitang dongshuihe. It was worshipped by officials of the Qing Dynasty, nobles, elites, Yuan Shikai and other people in power at the end of the Qing Dynasty and the beginning of the Republic of China, Sun Yat-sen, the pioneer of the Republic of China, Mao Zedong, the founder of the people's Republic of China, and so on. The success of Ejiao in the east of hongjitang promoted the development of hongjitang's career. Since 1910, Le Jingyu has successively established "ejiaozhuang in Shenrong of Jinan hongjitang" in Jiangjia alley, qianmenwai street, Beijing; established the west number of hongjitang in Jinan commercial port, the middle number of hongjitang in jingerweiyi Road, Jinan, and opened a medicine store in Xiguan, Jinan, etc. In the 1930s, the total income of hongjitang accounted for two-thirds of the total number of Tongrentang. Jinan hongjitang, Beijing Tongrentang and Hangzhou Huqingyutang were also known as the "three famous halls in China". Le Jingyu is also in charge of Jinan hongjitang and Beijing Tongrentang. Part of the rooms of hongjitang dongshuiejiao factory were from 1925 to 1927. It was also the seat of Shandong provincial Party committee, where the main leaders lived or worked. After the founding of the people's Republic of China, Le Jingyu, a senior and sickly man, was still invited by Chairman Mao and Premier Zhou. His nephew Le Songsheng was honored to receive Chairman Mao and Premier Zhou twice. In July 1955, the people's Government of Jinan City carried out the public-private joint transformation of all the old traditional Chinese medicine brands in the city with hongjitang as the leader, and established Jinan herbal medicine company (Jinan herbal medicine Station). In 1996, it was transformed into Jinan Pharmaceutical Group Co., Ltd., the predecessor of Shandong hongjitang Pharmaceutical Group Co., Ltd. In 2008, Shandong hongjitang Pharmaceutical Group Co., Ltd. invested to establish "Shandong hongjitang donkey hide gelatin Co., Ltd." in order to excavate precious traditional Chinese medicine products and restore the traditional production technology of donkey hide gelatin in the east stream of hongjitang. The company targeted to allocate personnel, seek and reuse the existing old pharmacists and technicians, and teach the production technology of donkey hide gelatin in the east stream of hongjitang, which is a valuable traditional Chinese medicine Product protection development. After the efforts in recent years, Shandong hongjitang donkey hide gelatin Co., Ltd. resumed its production and listing after nearly 60 years of interruption in accordance with the old tradition, old technology, old formula and old selection materials. In October 2010, CCTV CCTV CCTV 4 "all over China" shot "resurrected ancient glue" which was broadcast in 170 countries in the world. Since last year, CCTV channels CCTV4, CCTV7, and cctv12 have successively broadcast special documentaries reflecting the history and culture of Ejiao in the east of hongjitang, such as "travel all over China - yellow mandarin jacket", "national treasure Archives - Jiutian tribute glue", "local - Xiaolou spring and Autumn", "witness - Legend of ancient glue", which fully affirmed and deeply reported this product with historical and cultural characteristics 。 In 2010, hongjitang dongshuiejiao "nine lifting and nine baking" production technology has been listed in the intangible cultural heritage; it has been rated as the top ten products with folk culture characteristics by Jinan City.

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